Cancer Cohort
Funder:
 KP Research Bank
Co-Investigator
: Monica Ter-Minassian

Center for Effectiveness & Safety Research (CESR)
Goal:
Develop, standardize and improve research infrastructure for inter-regional research studies and perform rapid turnaround research that addresses questions of interest to Kaiser Permanente and the nation.
Funder: KP Operational Funds (National)
Site Principal Investigator: Michael Horberg

Cohort Study of Patients with Disorders of Sex Development (DSD)
Goal:
 The goal of this proposal is to compare DSD (Disorders of Sex Development) Quality of Care Indicators (QCI) against actual DSD management delivered at large nationwide integrated HCSs. We will estimate the percentage of DSD patients who received care according to each QCI, compare incidence and prevalence of co-morbidities in DSD patients to the corresponding measures among frequency matched patients, and assess the proportion of prophylactic gonadectomies that show malignant or precursor lesions on the resulting pathology specimens.
Funder:
 NICHD 
Site Primary Investigator
: Suma Vupputuri

COMpAAAS Tripartite: ART-CC, KP, and VA
Goal:
The purpose of the overall study is to participate in a scientific collaboration across three grant partners to assemble data sets, including electronic health record data. Partners will interpret and disseminate results of the study through conference abstracts and manuscripts.
Funder:
National Institute of Health
Principal Investigator:
Michael Horberg

Database cohort study to assess the risk of serious angioedema in association with LCZ696 (sacubitril/valsartan; Entresto) use in Black patients with heart failure in the United States.
Goal:
This study will provide estimates of the incidence of angioedema among HF patients initiating sacubitril/valsartan and HF patients initiating an angiotensin-converting enzyme inhibitor (ACEI), with a primary focus on Black HF patients. These estimates will quantify the risk of angioedema among HF patients initiating sacubitril/valsartan compared to HF patients initiating an ACEI.
Investigator:
Douglas Roblin

Developing a Prescription Opioid Registry in Diverse Health Systems
Goal:
Building on past research, this project will establish the infrastructure to expand a prescription opioid registry across diverse health systems in the Addiction Research Network. Harmonized electronic health record data elements will be used to examine how changes in opioid use are associated with other patient outcomes, such as emergency department service utilization, benzodiazepine use, and use of other non-opioid medications (e.g., nonsteroidal anti-inflammatory drugs [NSAIDs] and gabapentin), and how this may vary by patient characteristics and across health systems.
Investigator:
Douglas Roblin

Development of Cirrhosis Registry
Goal:
The objective of the Cirrhosis Registry is to support internal, inter-regional and external research related to risk factors for cirrhosis and patient outcomes.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: 

Development of Chronic Kidney Disease (CKD) and End-Stage Renal Disease Registry
Goal:
The objective of this project is to support internal, inter-regional and external research related CKD and ESRD.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator:
Eric Watson

Development of an Immunization Registry
Goal:
The objective of the Immunization Registry is to support internal, inter-regional and external research related to vaccine surveillance, safety and effectiveness.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator:

Development of Virtual Data Warehouse (VDW) and Research Data Warehouse (RDW)
Goal:
The goal of this project is to provide a common set of data elements and structure to increase efficiency of developing and running scripts across different sites, allowing for more seamless research across multiple sites. The goal of the RDW is to create an integrated view from the multiple systems that house the data that constitute the Kaiser Permanante Electronic Health Records.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator:
Eric Watson

Enhancement of Hepatitis B & C Registries
Goal:
The goal of this project is to more fully develop the Hepatitis B and C registries to support internal, inter-regional and external research related to surveillance, treatment safety and effectiveness, comorbid conditions and patient outcomes.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator:

Establishing a Cohort to Study Cancers in Organ Transplant Recipients
Goal:
This pilot study will evaluate the feasibility of establishing a cohort of solid organ transplant recipient to study incident cancers in this high risk population.
Funder: National Cancer Institute via the Cancer Research Network Pilot Project Program U24CA171524
Principal Investigator: Michael Horberg

Feasibility and Assessment of a Cascade Traceback Screening (FACTS) Program  
Funder: National Cancer Institute
Principal Investigator:Cabell Jonas, PhD, Alanna Rahm, PhD, Nora Henrikson, PhD

FDA Mini-Sentinel Program
Goal:
Develop a national research data infrastructure that supports rapid turnaround queries regarding public health concerns
Funder: FDA
Site Principal Investigator: Michael Horberg

HIV Infection, Use of Tenofovir and Other Antiretrovirals, and Risk of Fatal and Non-Fatal Comorbidities: Cohort study in Kaiser Permanente
Goal:
The purpose of the overall study is to primarily compare the incidence rate of fatal and non-fatal comorbidities in HIV patients with incidence rates among matched HIV-uninfected controls, and HIV-uninfected individuals prescribed PrEP.
Funder:
Gilead, Inc.
Multiple Principal Investigator:
Michael Horberg

HIV Status and Incidence and Outcomes of Heart Failure
Goal:
The overall purpose of this study is to work with our clinical and policy leaders in HIV and CHF care to quantify the risk of congestive heart failure (CHF) among HIV-infected patients, which antiretroviral therapy medications have increased risk for CHF and which may be protective, as well as develop care patterns for CHF among our HIV-infected patients.
Funder:
National Heart, Lung, and Blood Institute
Co-Investigator:
Micheal Horberg

Implementing Computerized Substance Use and Depression Screening and Evidence-Based Treatments in an HIV Primary Care Population
Goal:
The purpose of the overall study is to address the important topic of alcohol, smoking and other substance use and comorbidity screening and treatment among HIV-impacted patients. This study represents an important next step in the evolution of our top-quality HIV care in the context of an aging HIV patient population and has important implications beyond the Kaiser Permanente system.
Funder:
National Institute on Alcohol, Abuse and Alcoholism
Principal Investigator:
Michael Horberg

Interregional Utilization of Low-Value Interventions for Cancer Care
Goal:
The goals of this project are to assess the feasibility of measuring adherence with the five American Board of Internal Medicine/American Society of Clinical Oncology “Choosing Wisely” practices for low-value cancer care, and to measure adherence and the system-level factors associated with adherence to these measures within three Kaiser Permanente regions.
Funder: CESR
Site Principal Investigator: Michael Horberg

Kaiser Permanente HIV Quality Improvement and Performance Program
Goal:
We seek to determine quantitative measures of HIV care and outcomes in Kaiser Permanente. We seek to then initiate quality improvement programs where we determine there are opportunities for improvement.
Funder
: Care Management Institute/The Permanente Federation/Kaiser Health Plans
Project and Overall Clinical Leader: Michael Horberg

Kaiser Permanente Research Bank
Goal:
 The Kaiser Permanente (KP) Research Bank is a nationwide research bank that facilitates studies related to the prevention, diagnosis and treatment of disease.
Funder: Kaiser Permanente Community Benefit, National Program Office
Site Principal Investigator: Michael Horberg

KPMA Hepatitis Registries
Goal:
Development of the hepatitis B and C registries are critical to ongoing research efforts for KPMA. The hepatitis C registry case finding and registry population is ongoing, with development of hepatitis B and cirrhosis registries next. Both epidemiologic and clinical applications are anticipated.
Funder: Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator (MAPRI):
Michael Horberg

KPMA HIV Registry
Goal:
Develop the HIV registry that closely aligns with the other KP regions’ case definitions. This registry will be used to identify populations for potential research studies, clinical trials, and clinical applications as required.
Funder:
Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator:
Michael Horberg

KPMA Sickle Cell Disease Registry
Goal: Develop a sickle cell disease registry that closely aligns with the other KP regions’ case definitions. The registry will be used to facilitate future IRB-approved research based on known cases within the registry, to improve care, and to enhance clinical decision making.
Funder: Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator (MAPRI):
Michael Horberg

North American AIDS Cohorts Collaboration on Research and Design (NA-ACCORD)
Goal:
This is the North America response to IeDEA, and for which Kaiser Permanente Northern California participates. It is a collaborative cohort compendium and analysis for purposes of achieving sufficient power to address issues that could not be adequately addressed by single cohorts.
Funder:
National Institute of Allergy and Infectious Diseases
Site Principal Investigator
: Michael Horberg

Terry Beirn CPCRA Clinical Trials Unit: A City-wide DC Cohort of HIV Infected Persons in Care in the District of Columbia
Goal:
The overall purpose of this study is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes in outpatients with HIV/AIDS receiving care in Washington, DC, with the goal of improving HIV/AIDS care in DC.
Funder:
National Institute on Drug Abuse
Site Principal Investigator:
Michael Horberg

The Effect of Health Information Exchange on the Duplication of Radiological Services
Goal:
Determine if comprehensive health information exchange through the electronic health record reduces the rate of follow-up x-rays for simple bone fractures.
Funder: KPMAS Community Benefit
Principal Investigator: Michael Horberg

Using Electronic Health Records Effectively: The Influence of Advanced Training on The Use of Key EHR Features
Goal:
Determine if training on electronic health records workflows improves the use of features such as problem lists and medication lists that are important for meaningful use of EHRs.
Funder: KPMAS Community Benefit
Principal Investigator: Michael Horberg

Virtual Tumor Registry
Goal:
The goal of of this project is to create resources for future internal research projects, as well as inter-regional and extramural research collaborations.
Funder:Kaiser Permanente Community Benefit Program
Principal Investigator: Michael Horberg