Open and Enrolling Clinical Trials

Pending IRB Approval: NCI COVID-19 in Cancer Patients Study (N-CCaPS): A Longitudinal Natural History Study
Sponsor: National Cancer Institute
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Phase 1b Study to Evaluate the Safety and Clinical Activity of AB122 in Biomarker-Selected Participants with Advanced Solid Tumors
Sponsor: Arcus Biosciences, Inc.
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Prospective, Block Stratified Clinical Trial to Evaluate the Performance and Operation of the Brevera Breast Biopsy System (Hologic-16-05B)
Sponsor: Hologic, Inc.
Principal Investigator: Ainsley MacLean, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Randomized, Phase II/III Study of Pegylated Lipsomal Doxorubicin and CTEP-Supplied Atezolizumab versus Pegylated Liposomal Doxorubicin/Bevacizumab and CTEP-Supplied Atezolizumab versus Pegylated Liposomal Doxorubicin/Bevacizumab in Platinum Resistant Ovarian Cancer (NRG-GY009)
Sponsor: NRG Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial
Sponsor: Alliance for Clinical Trials in Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

An Observational Study Profiling Biospecimens from Cancer Patients to Screen for Molecular Alterations (STR-001-001)
Sponsor: Strata Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or Without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer
Sponsor: NRG Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Tomosynthesis Mammographic Imaging Screening Trial (TMIST)
Sponsor: Southwest Oncology Group (SWOG)
Principal Investigator: Ainsley MacLean, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST_A151216): A screening trial for A081105, E4512 and EA5142
Sponsor: Alliance for Clinical Trials in Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Randomized Study of Erlotinib Vs Observation in Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC) (ALCHEMIST_A081105 [Erlotinib])
Sponsor: Alliance for Clinical Trials in Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib Versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein (ALCHEMIST_E4512 [Crizotinib])
Sponsor: Alliance for Clinical Trials in Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Adjuvant Nivolumab in Resected Lung Cancers (ANVIL)-A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers (ALCHEMIST_EA5142 [Nivolumab])
Sponsor: Alliance for Clinical Trials in Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel With or Without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer (NRG-BR003)
Sponsor: NRG Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Adenoma and Second Primary Prevention Trial (PACES)
Sponsor: Southwest Oncology Group (SWOG)
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

MRI and Mammography Before Surgery in Patients With Stage I-II Breast Cancer (Pre-Op MRI-A011104/ACRIN 6694)
Sponsor: Alliance for Clinical Trials in Oncology, American College of Radiology Imaging Network, and National Cancer Institute (NCI)
Principal Investigator: Amadea Tette, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer (Everolimus-SWOG S1207)
Sponsor: Southwest Oncology Group (SWOG)
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients With High Grade Glioma (ALLIANCE A0221101)
Sponsor: Alliance for Clinical Trials of Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Breast Cancer WEight Loss Study (BWEL Study)
Sponsor: Alliance for Clinical Trials of Oncology
Principal Investigator: Leon Hwang, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

Pending IRB Approval: Utilization of Target Ranges to Treat Persons with Parkinson’s Disease by Objective Measurement Using the Personal KinetiGraph® (PKG®) compared to Standard of Care Assessment (TARGET-PwP)
Sponsor: Global Kinetics Pty Ltd
Principal Investigator: Ejaz Shamim, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

A Phase III Open-Label Clinical Study to Evaluate the Safety and Tolerability of Rebiotix RBX2660 (microbiota suspension) in Subjects with Recurrent Clostridium difficile Infection (Rebiotix Open-Label)
Sponsor: Rebiotix Inc.
Principal Investigator: David Yoho, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768

An open-label, non-randomized, prospective observational cohort study to assess post-procedural outcomes in two cohorts of women who chose to undergo either hysteroscopic sterilization (Essure®) or laparoscopic tubal sterilization (POET-ESSURE)
Sponsor: Bayer HealthCare, LLC
Principal Investigator: Kevin Smith, MD
Contact: Leslie Greenberg, Clinical Trial Manager, 301-816-6768