A City-wide DC Cohort of HIV Infected Persons in Care in the District of Columbia
Goal: The overall purpose of this study is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes in outpatients with HIV/AIDS receiving care in Washington, DC, to improve HIV/AIDS care in DC.
Funder: National Institute on Drug Abuse
Site Principal Investigator: Michael Horberg
Assessing Syndemics of Cardiovascular Disease in People with and without HIV
Goal: This study will explore the role of social demographic and community factors in the impact of HIV on heart disease and vice versa. It will also explore the use of KP Research Bank for data and blood samples to explore the role of genetics in these morbidities.
Funder: National Heart, Lung, and Blood Institute
Site Principal Investigator: Michael Horberg
Cabotegravir PrEP: Actionable Robust Evidence for Translation into Practice (CABARET)
Goal: This study will explore what factors contribute to the employment of long-acting HIV Pre-Exposure Prophylaxis and how this can be encouraged and grown in use to prevent HIV infection within an integrated care system.
Funder: National Institutes of Mental Health
Site Principal Investigator: Michael Horberg
Center for Effectiveness & Safety Research (CESR)
Goal: Develop, standardize, and improve research infrastructure for inter-regional research studies and perform rapid turnaround research that addresses questions of interest to Kaiser Permanente and the nation.
Funder: KP Operational Funds (National)
Site Principal Investigator: Michael Horberg
Cohort Study of Patients with Disorders of Sex Development (DSD)
Goal: The goal of this proposal is to compare DSD (Disorders of Sex Development) Quality of Care Indicators (QCI) against actual DSD management delivered at large nationwide integrated HCSs. We will estimate the percentage of DSD patients who received care according to each QCI, compare incidence and prevalence of co-morbidities in DSD patients to the corresponding measures among frequency-matched patients, and assess the proportion of prophylactic gonadectomies that show malignant or precursor lesions on the resulting pathology specimens.
Funder: NICHD
Site Primary Investigator: Suma Vupputuri
COMpAAAS Tripartite: ART-CC, KP, and VA
Goal: The purpose of the overall study is to participate in a scientific collaboration across three grant partners to assemble data sets, including electronic health record data. Partners will interpret and disseminate the results of the study through conference abstracts and manuscripts.
Funder: National Institute of Health
Principal Investigator: Michael Horberg
Development of Chronic Kidney Disease (CKD) and End-Stage Renal Disease Registry
Goal: The objective of this project is to support internal, inter-regional, and external research related to CKD and ESRD.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Eric Watson
Development of Virtual Data Warehouse (VDW) and Research Data Warehouse (RDW)
Goal: The goal of this project is to provide a common set of data elements and structures to increase the efficiency of developing and running scripts across different sites, allowing for more seamless research across multiple sites. The goal of the RDW is to create an integrated view from the multiple systems that house the data that constitute the Kaiser Permanente Electronic Health Records.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Eric Watson
HIV Infection, Use of Tenofovir and Other Antiretrovirals, and Risk of Fatal and Non-Fatal Comorbidities: Cohort Study in Kaiser Permanente
Goal: The purpose of the overall study is to primarily compare the incidence rate of fatal and non-fatal comorbidities in HIV patients with incidence rates among matched HIV-uninfected controls, and HIV-uninfected individuals prescribed PrEP.
Funder: Gilead, Inc.
Multiple Principal Investigator: Michael Horberg
HIV Status and Incidence and Outcomes of Heart Failure
Goal: The overall purpose of this study is to work with our clinical and policy leaders in HIV and CHF care to quantify the risk of congestive heart failure (CHF) among HIV-infected patients, which antiretroviral therapy medications have increased risk for CHF and which may be protective, as well as develop care patterns for CHF among our HIV-infected patients.
Funder: National Heart, Lung, and Blood Institute
Co-Investigator: Micheal Horberg
Implementing Computerized Substance Use and Depression Screening and Evidence-Based Treatments in an HIV Primary Care Population
Goal: The purpose of the overall study is to address the important topic of alcohol, smoking, and other substance use and comorbidity screening and treatment among HIV-impacted patients. This study represents an important next step in the evolution of our top-quality HIV care in the context of an aging HIV patient population and has important implications beyond the Kaiser Permanente system.
Funder: National Institute on Alcohol, Abuse, and Alcoholism
Principal Investigator: Michael Horberg
Kaiser Permanente HIV Quality Improvement and Performance Program
Goal: We seek to determine quantitative measures of HIV care and outcomes in Kaiser Permanente. We seek to initiate quality improvement programs where we determine there are opportunities for improvement.
Funder: Care Management Institute/The Permanente Federation/Kaiser Health Plans
Project and Overall Clinical Leader: Michael Horberg
Kaiser Permanente Research Bank
Goal: The Kaiser Permanente (KP) Research Bank is a nationwide research bank that facilitates studies related to the prevention, diagnosis, and treatment of disease.
Funder: Kaiser Permanente Community Benefit, National Program Office
Site Principal Investigator: Michael Horberg
Kaiser PrEP Data
Goal: This will provide additional data and demographics to assess the United States’ use of HIV Pre-Exposure Prophylaxis and study the demographics and opportunities for its use within the USA.
Funder: US Center for Disease Control
Principal Investigator (MAPRI): Michael Horberg
KPMA Hepatitis Registries
Goal: The development of the hepatitis B and C registries is critical to ongoing research efforts for KPMA. The hepatitis C registry case finding and registry population is ongoing, with the development of hepatitis B and cirrhosis registries next. Both epidemiologic and clinical applications are anticipated.
Funder: Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator (MAPRI): Michael Horberg
KPMA HIV Registry
Goal: Develop an HIV registry that closely aligns with the other KP regions’ case definitions. This registry will be used to identify populations for potential research studies, clinical trials, and clinical applications as required.
Funder: Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator: Michael Horberg
KPMA Sickle Cell Disease Registry
Goal: Develop a sickle cell disease registry that closely aligns with the other KP regions’ case definitions. The registry will be used to facilitate future IRB-approved research based on known cases within the registry, improve care, and enhance clinical decision-making.
Funder: Kaiser Permanente Mid-Atlantic Community Benefits
Principal Investigator (MAPRI): Michael Horberg
North American AIDS Cohorts Collaboration on Research and Design (NA-ACCORD)
Goal: This is the North American response to IeDEA, in which Kaiser Permanente Northern California participates. It is a collaborative cohort compendium and analysis for the purpose of achieving sufficient power to address issues that could not be adequately addressed by single cohorts.
Funder: National Institute of Allergy and Infectious Diseases
Site Principal Investigator: Michael Horberg
ORION Observational Research on the Impact and Outcomes of Norovirus
Goal: The goal of the ORION study is to better understand how often adults experience stomach illness, also known as acute gastroenteritis (or AGE), and how that illness impacts their quality of life. For more information, visit ORION .
Funder: Moderna
Site Principal Investigator: Michael J. Miller
Sickle Cell Disease Registry
Goal: The goal of this project is to monitor Sickle Cell Disease incidence, treatment, and vaccinations of patients diagnosed at Kaiser Permanente Mid-Atlantic States.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Monica Ter-Minassian
Vaccine Safety Datalink (VSD) Project
Goal: KPMAS has joined the VSD as the site for the Mid-Atlantic. We will explore and report on vaccine safety and provide regular data updates for assigned projects and for advanced signals for new and established vaccinations. This is performed for all communities and age groups.
Funder: CDC
Principal Investigator: Michael Horberg
Virtual Tumor Registry
Goal: The goal of this project is to create resources for future internal research projects, as well as inter-regional and extramural research collaborations.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Michael Horberg