Cabell Jonas, PhD

MCJ_2019

Senior Research Program Consultant, Operations Research Associate Investigator

301-816-7371
Cabell.Jonas@kp.org

Role:

Cabell Jonas joined the Mid-Atlantic Permanente Medical Group in 2014. Dr. Jonas is a Senior Research Program Consultant, Operations Research Associate Investigator within the Mid-Atlantic Permanente Research Institute (MAPRI). She has responsibilities in the areas of genetics/genomics and serves as the regional operations lead for the KP Research Bank. Regionally, she has implemented several high-profile regional programs in the areas of hepatitis C, hepatitis B, and hepatocellular carcinoma surveillance and conducts research in collaboration with the medical group.

Dr. Jonas received her Bachelor of Science degree in Biology from Virginia Tech, and her Ph.D. in Cellular & Molecular Biology from The University of Wisconsin-Madison. Prior to joining the Mid-Atlantic Permanente Medical Group, she was a consultant at The Advisory Board Company, a health care consulting firm based in Washington, D.C.

  1. FEASIBILITY AND ASSESSMENT OF A CASCADE TRACEBACK SCREENING PROGRAM – FACTS (Link )
    Funder:
    National Cancer Institute
    Principal Investigators: Cabell Jonas, PhD, Alanna Rahm, PhD, Nora Henrikson, PhD
  2. Kaiser Permanente Precision Medicine Assessment and Response
    Goal: The KP Precision Medicine Assessment and Response project conducted physician and patient surveys to assess attitudes, knowledge and readiness for genetics and precision medicine.
    Funder: Garfield Memorial Fund
    Principal Investigator: Elizabeth A. McGlynn, PhD
    Site Principal Investigator: Cabell Jonas, PhD
  3. Kaiser Permanente & Strategic Partners Patient Outcomes Research To Advance Learning (PORTAL) Network
    Goal: PORTAL is a new network that brings together four leading healthcare delivery systems: Kaiser Permanente, Group Health Cooperative, HealthPartners, and Denver Health. The 11 research centers affiliated with these systems collaborate with patients, clinicians, and operational leaders to develop the infrastructure necessary to create a highly functioning clinical data research network.
    Funder: Patient-Centered Outcomes Research Institute (PCORI)
    Site Principal Investigator
    : Michael Horberg, MD
  4. Kaiser Permanente Research Bank
    Goal:
    The Kaiser Permanente (KP) Research Bank is a nationwide research bank that facilitates studies related to the prevention, diagnosis and treatment of disease.
    Funder: Kaiser Permanente Community Benefit, National Program Office
    Site Principal Investigator: Michael Horberg, MD
  5. PORTAL Network – Congenital Heart Defect Pilot Study
    Goal:
    To evaluate a natural language processing algorithm for identifying and classifying congenital heart defects. To field a patient survey in collaboration with the Adult Congenital Heart Association on clinical and research topics.
    Funder: PORTAL Network
    Principal Investigator: Alan S. Go, MD
    Site Principal Investigator: Cabell Jonas, PhD
  1. Burnett-Hartman A, Blum-Barnett E, Carroll N, Madrid S, Jonas C, Janes K, Alvarado M,  Bedoy R,  Paolino V, Aziz N,  McGlynn E. “Return of research-related genetic test results and genetic discrimination concerns: facilitators and barriers of genetic research participation in diverse groups.”
  2. Carroll N, Blum-Barnett E, Madrid S, Jonas C, Janes K, Alvarado M, Bedoy R, Paolino V, Aziz N, McGlynn E, Burnett-Hartman A, “Demographic Differences in the Utilization of Clinical and Direct-to-Consumer Genetic Testing,” J Genet Couns. 2019
    Abstract
  3. Jonas MC, Loftus B, Horberg MA. The Road to Hepatitis C Virus Cure: Practical Considerations from a Health System’s Perspective. Infect Dis Clin North Am. 2018 Jun;32(2):481-493.
  4. Jonas MC, Rodriguez CV, Redd J, Sloane DA, Winston BJ, Loftus BC. Streamlining Screening to Treatment: The Hepatitis C Cascade of Care at Kaiser Permanente Mid-Atlantic States. Clin Infect Dis. 2016 Feb 16.
    PubMed Abstract
  5.  Jonas CSuwannarat P,  Burnett-Hartman A,  Carroll N,  Turner M,  Janes K,  Truong C,  Blum-Barnett E,  Aziz N,  McGlynn E. “Physician Experience with Direct-to-Consumer Genetic Testing in Kaiser Permanente.” J Pers Med. 2019 Nov 1, 9(4), 47
    Abstract
  6. Pehar M, Jonas C, Hare T, Puglielli L. “SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.” Journal of Biological Chemistry. 2012 Aug 24;287(35):29921-30.
  7. Jonas C, Pehar M, Puglielli L. “AT-1 is the ER-Membrane Acetyl-CoA Transporter and is Essential for Cell Viability.” Journal of Cell Science, Oct 1;123 (Pt 19):3378-88, 2010.
  8. Jonas C, Costantini C, Puglielli L. “PCSK9 is Required for the Disposal of Non-Acetylated Intermediates of the Nascent Membrane Protein BACE1.” EMBO Reports, Sep;9(9):916-22, 2008.
  9. Costantini C, Ko M, Jonas C, Puglielli L. “A Reversible Form of Lysine Acetylation in the ER and Golgi Lumen Controls the Molecular Stabilization of BACE1.” Biochemical Journal, 407(3): 383-395, 2007.
  1. Oral Presentation: Dr. Cabell Jonas, researcher with the Mid-Atlantic Permanente Research Institute, discusses the institute’s research bank, a way that all Kaiser Permanente members can contribute to the future of health 2020.  YouTube Link
  2. Oral Presentation: Transforming Hepatitis B Care in Kaiser Permanente Mid-Atlantic States Through a Registry and Coordinator Supported Pathway. Health Care Systems Research Network conference 2019.
  3. Oral Presentation: Ongoing Community Engagement – Successes and Lessons Learned from the KP Research Bank’s Regional and National Community Advisory Boards and PORTAL’s Patient Engagement Council. Health Care Systems Research Network conference 2019.
  4. Poster Presentation: Awareness of and Referrals from Direct-to-Consumer Genetic Testing and Pharmacogenomic Testing:
    Results from the Kaiser Permanente Physician Survey on Genetics in Health Care, Research, and Precision Medicine.American College of Medical Genetics conference 2019. ACMG Link
  5. National Webinar: Hepatitis C Care Pathway in KP Mid-Atlantic States – 2018 James A. Vohs Award Winner. KP Learning Forum. Available at (internal audiences only): Webinar
  6. Oral Presentation: 2018 Vohs Award Winner | The Hepatitis C Care Cascade: Increasing Comprehensive Screening and Diagnosis, Kaiser Permanente National Quality Conference, 2019.
    KP Proud
  7. Poster Presentation: Development of a Physician Survey on Genetics in Health Care, Research, and Precision Medicine within Kaiser Permanente. Health Care Systems Research Network conference 2018.
  8. Poster Presentation: Hepatitis C Cascade of Care at KP Mid-Atlantic States: The Laboratory Perspective. Health Care Systems Research Network conference 2018.
  9. Oral Presentation: Hepatitis Track: Hepatitis Care Pathway – Aiming for Universal HIV and HCV Testing at KP
    National HIV, Hepatitis & STD Conference 2017
  10. Oral Presentation: Streamlining Screening to Treatment: The HCV Care Cascade. Kaiser Permanente National Quality Conference 2017.
  11. Oral Presentation: Streamlined Hepatitis C Diagnosis and Treatment. EPIC Expert Group Meeting. 2016.